Zydus Cadila receives DCGI nod for Phase-I trial of ZYIL1

On Monday, Drugs Controller General of India (DCGI) granted Zydus Cadila the permission from to initiate Phase-1 clinical trial of its novel molecule ZYIL1, indicated for use as an inhibitor for inflammation condition ”NLRP3”.

“It has received permission to initiate the Phase-1 clinical trial of ZYIL1, a novel oral small molecule NLRP3 inhibitor candidate. NLRP3 inflammasomes are involved in the inflammation process,” said Zydus Cadila.

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This harmful inflammation within the body leads to the onset and development of various kinds of diseases, including Acute Respiratory Distress Syndrome (ARDS), auto-immune diseases, inflammatory diseases, cardiovascular diseases, metabolic disorders, Gastro-intestinal diseases (inflammatory bowel disease), renal diseases and CNS diseases, the company added.

“We will study the safety, tolerability, pharmacokinetics and pharmacodynamics of ZYIL1 in this Phase I clinical trial in healthy human volunteers. We are committed to developing these pioneering novel treatments to the clinic for the patients in need,” says Chairman of Zydus Cadila Healthcare Pankaj R Patel.

Last month, Zydus Cadila had filed the investigational new drug application for ZYIL1, positioned for management of critically ill COVID-19 patients.

Shares of Cadila Healthcare were trading 1.85 per cent higher at Rs 479.70 apiece on BSE