Global demand for high-quality plasmid DNA continues to rise as automation, regulatory compliance, and large-scale manufacturing shape the next phase of biotech innovation.
Austin, Nov. 03, 2025 (GLOBE NEWSWIRE) — Plasmid Purification Market Size & Growth Analysis
According to SNS Insider, the global Plasmid Purification Market was valued at USD 1.96 billion in 2024 and is expected to reach USD 4.74 billion by 2032, growing at a CAGR of 11.67% during the forecast period of 2025–2032. The U.S. market is anticipated to rise from USD 0.43 billion in 2024 to USD 0.95 billion by 2032, reflecting a strong 10.52% CAGR, supported by advanced biopharmaceutical infrastructure, regulatory approvals, and continuous R&D investments in gene therapy and mRNA vaccine manufacturing.
The increasing need for purified, high-quality plasmid DNA for gene therapy, vaccine production, and molecular biology applications is driving market expansion. The ongoing adoption of innovative purification techniques, such as anion-exchange chromatography and silica membrane binding, has significantly improved yield, purity, and scalability. The industry’s focus on automation, personalization, and process efficiency along with the rising number of gene-based therapies continues to propel the global plasmid purification market forward.
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Plasmid Purification Market Overview
The process of isolating plasmid DNA is important for research, gene therapy, and vaccine development. The growing demand for gene therapy and mRNA vaccines is driving the need for highly purified plasmid DNA.
Manufacturing companies are moving towards ‘GMP’ standards to meet clinical and commercial needs. Automated systems from companies like Thermo Fisher and Bio-Rad are making production consistent and faster. The market is benefiting from regulatory approvals for new manufacturing facilities, such as the approval for Thermo Fisher’s facility in California.
Major Players in the Plasmid Purification Market Include:
- Agilent Technologies Inc.
- Applied Biological Materials Inc.
- Bio-Rad Laboratories Inc.
- GenScript Biotech Corporation
- MCLAB
- Merck KGaA
- MP Biomedicals
- New England Biolabs
- Promega Corporation
- QIAGEN
- Qiagen N.V.
- Sartorius AG
- Takara Bio Inc.
- Thermo Fisher Scientific Inc.
- Zymo Research and Other Key Participants
Plasmid Purification Market Segment Insights:
By Product & Service
Plasmid purification market share stood at 75.3%, with the products segment held the major share in 2024. The growth is driven by high demand, grounded on research, diagnostics, and therapy applications. The services segment is expected to witness highest growth in the market in upcoming years due to the growing trend of outsourcing among pharmaceutical companies and academic research institutes.
By Grade
With a 64.42% share, molecular-grade plasmid DNA dominated the market due to its general use in basic research, diagnostics, and regular laboratory procedures. The transfection-grade segment is projected to grow at the fastest CAGR due to the rising demand for high-purity, endotoxin-free plasmid DNA drives.
By Application
The cloning and protein expression segment on is leading the market with a 52.7% revenue share, supported by the rising demand for recombinant protein generation in medication development and academic research, further boosting the market share. The transfection and gene editing segment is expected to witness high growth throughout the forecast period driven by the synthetic biology, CRISpen technologies, and another modern gene-editing platform that demand high-quality and contaminant-free plasmid DNA.
By End-Use
With 44.2% of the revenue, academia and research institutions held the highest plasmid purification market share in 2024 due to the leading fundamental research and educational activities. The contract research organizations (CROs) segment is expected to be the fastest-growing segment as biopharmaceutical companies outsource difficult R&D and clinical manufacturing activities.
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Regional Analysis:
North America led the market in 2024, supported by robust biotechnology infrastructure, significant R&D spending, and a rise in gene therapy and vaccine-related research. The main contributor is the U.S., housing major market participants, such as Thermo Fisher Scientific and New England Biolabs (NEB).
Asia Pacific is emerging as the fastest-growing region during 2025 to 2032 due to rising university research activity, increasing biotechnology investments, and expanding pharmaceutical manufacturing.
Recent Developments in the Plasmid Purification Market:
- In June 2024, Thermo Fisher Scientific launched the Thermo Scientific KingFisher PlasmidPro, the first fully automated plasmid purification system designed to accelerate therapeutic development. This innovation delivers high-purity plasmid DNA in just 75 minutes, cutting process time by 50% and eliminating the need for centrifugation, marking a major advancement in automation and efficiency in the market.
- In November 2024, Zymo Research received the CE IVD mark for its Quick-DNA/RNA Viral MagBead Kit, allowing its use for in vitro diagnostic applications across EU member states. This certification facilitates broader adoption of the kit in clinical settings, supporting high-throughput purification of viral DNA/RNA, including SARS-CoV-2.
Exclusive Sections of the Report (The USPs):
- GENE AND CELL THERAPY TRIALS INSIGHTS – helps you evaluate the growing demand for plasmid DNA driven by the surge in global gene and cell therapy clinical trials, highlighting key therapeutic areas and pipeline expansion trends.
- REGIONAL USAGE TRENDS IN PLASMID PURIFICATION – helps you identify leading geographies in adoption, showcasing regional variations in production scalability, compliance standards, and technology penetration.
- R&D INVESTMENT IN GENETIC ENGINEERING AND BIOLOGICS – helps you assess how intensified research funding and partnerships in genetic engineering are accelerating plasmid innovation for next-gen therapeutics and vaccines.
- CDMO AND BIOPHARMACEUTICAL CAPACITY UTILIZATION RATES – helps you understand operational efficiency levels and manufacturing load across Contract Development and Manufacturing Organizations (CDMOs) to gauge supply-demand alignment.
- PATENT FILINGS AND APPROVAL LANDSCAPE – helps you track innovation trends, intellectual property expansion, and regulatory progress for plasmid-based technologies shaping market competitiveness and entry barriers.
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Plasmid Purification Market Report Scope
| Report Attributes | Details |
| Market Size in 2024 | USD 1.96 billion |
| Market Size by 2032 | USD 4.74 billion |
| CAGR | CAGR of 11.67% From 2025 to 2032 |
| Base Year | 2024 |
| Forecast Period | 2025-2032 |
| Historical Data | 2021-2023 |
| Key Segments | By Product & Service [Products, Services]
By Grade [Molecular-Grade, Transfection Grade] By Application [Cloning & Protein Expression, Transfection & Gene Editing, Others] By End Use [Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Contract Research Organizations] |
| Regional Analysis/Coverage | North America (US, Canada), Europe (Germany, UK, France, Italy, Spain, Russia, Poland, Rest of Europe), Asia Pacific (China, India, Japan, South Korea, Australia, ASEAN Countries, Rest of Asia Pacific), Middle East & Africa (UAE, Saudi Arabia, Qatar, South Africa, Rest of Middle East & Africa), Latin America (Brazil, Argentina, Mexico, Colombia, Rest of Latin America). |
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